GAF summary
Found 19456 annotations in 19475 lines.
GAF Validation Summary Errors are reported first.
For rule GO_AR:0000005 (http://www.geneontology.org/GO.annotation_qc.shtml#GO_AR:0000005) No ISS or ISS-related annotations to 'protein binding ; GO:0005515', there are 3 violations with type Error.
For rule GO_AR:0000003 (http://www.geneontology.org/GO.annotation_qc.shtml#GO_AR:0000003) Annotations to 'binding ; GO:0005488' and 'protein binding ; GO:0005515' should be made with IPI and an interactor in the 'with' field, there are 3 violations with type Warning.
GAF Prediction Summary
No inferences or predictions to report.
Used Ontology Summary
go/extensions/go-gaf go/releases/2019-12-08/extensions/go-gaf.owl
This report generated on 2019-12-09
!gaf-version: 2.1
!
!The set of protein accessions included in this file is based on UniProt complete proteomes, which may provide more than one protein per gene.
!They include all Swiss-Prot entries for the species plus any TrEMBL entries that have an Ensembl DR line. The TrEMBL entries are likely to overlap with the Swiss-Prot entries or their isoforms.
!If a particular protein accession is not annotated with GO, then it will not appear in this file.
!
!Note that the annotation set in this file is filtered in order to reduce redundancy; the full, unfiltered set can be found in
!ftp://ftp.ebi.ac.uk/pub/databases/GO/goa/UNIPROT/goa_uniprot_all.gaf.gz
!
!Generated: 2019-11-11 16:00
!GO-version: http://purl.obolibrary.org/obo/go/releases/2019-11-09/extensions/go-plus.owl
!
No 'NOT' annotations to 'protein binding ; GO:0005515'
IEP and HEP usage is restricted to terms from the Biological Process ontology
IPI should not be used with GO:0003824 catalytic activity or descendents
No annotations should be made to uninformative high level terms
ND evidence code should be to root nodes only, and no terms other than root nodes can have the evidence code ND
Taxon-appropriate annotation check
Dual species taxon check
With/From: IC annotations require a With/From GO ID
IDA annotations must not have a With/From entry
IPI annotations require a With/From entry
Automatic repair of annotations to merged or obsoleted terms
UniProtKB F1PAA4 CDH1 GO:0005913 GO_REF:0000107 IEA UniProtKB:P12830|ensembl:ENSP00000261769 C Cadherin-1 CDH1 protein taxon:9615 20191109 Ensembl UniProtKB:F1PAA4
UniProtKB F1PUP2 PTPRM GO:0005913 GO_REF:0000024 ISS UniProtKB:P28827 C Protein tyrosine phosphatase, receptor type M PTPRM protein taxon:9615 20120320 UniProt UniProtKB:F1PUP2
UniProtKB J9NV64 CD99L2 GO:0005913 GO_REF:0000107 IEA UniProtKB:Q8BIF0|ensembl:ENSMUSP00000042606 C CD99 molecule like 2 CD99L2 protein taxon:9615 20191109 Ensembl UniProtKB:J9NV64
UniProtKB J9P6A9 DSC2 GO:0005913 GO_REF:0000107 IEA UniProtKB:P55292|ensembl:ENSMUSP00000074702 C Desmocollin 2 DSC2 protein taxon:9615 20191109 Ensembl UniProtKB:J9P6A9
UniProtKB L7N0D0 CORO1B GO:0005913 GO_REF:0000107 IEA UniProtKB:P62136|ensembl:ENSP00000326031 C Serine/threonine-protein phosphatase CORO1B protein taxon:9615 20191109 Ensembl UniProtKB:L7N0D0
Aspect can only be one of C, P, F and should be repaired using the GO term
All IEAs over a year old are removed
Deprecated GO_REFs are not allowed
IBA annotations should ONLY be assigned_by GO_Central and have PMID:21873635 as a reference
Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants
Qualifier: IKR evidence code requires a NOT qualifier
Check for valid combination of evidence code and GO_REF
The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms.
UniProtKB E2QRZ7 PEX14 GO:0051260 GO_REF:0000107 IEA UniProtKB:O75381|ensembl:ENSP00000349016 P Uncharacterized protein PEX14 protein taxon:9615 20191109 Ensembl UniProtKB:E2QRZ7
UniProtKB E2QY07 ACTN1 GO:0042803 GO_REF:0000024 ISS UniProtKB:P05094-2 F Actinin alpha 1 ACTN1 protein taxon:9615 20150407 AgBase UniProtKB:E2QY07
UniProtKB E2QY46 DCXR GO:0051289 GO_REF:0000107 IEA UniProtKB:Q7Z4W1|ensembl:ENSP00000303356 P Dicarbonyl and L-xylulose reductase DCXR protein taxon:9615 20191109 Ensembl UniProtKB:E2QY46
UniProtKB E2QY46 DCXR GO:0051289 GO_REF:0000107 IEA UniProtKB:Q91X52|ensembl:ENSMUSP00000026144 P Dicarbonyl and L-xylulose reductase DCXR protein taxon:9615 20191109 Ensembl UniProtKB:E2QY46
UniProtKB E2R0I9 G6PD GO:0042803 GO_REF:0000107 IEA UniProtKB:P11413|ensembl:ENSP00000377192 F Glucose-6-phosphate 1-dehydrogenase G6PD protein taxon:9615 20191109 Ensembl UniProtKB:E2R0I9
UniProtKB E2R3B5 DPY30 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q9C005|ensembl:ENSP00000345837 F Dpy-30 histone methyltransferase complex regulatory subunit DPY30 protein taxon:9615 20191109 Ensembl UniProtKB:E2R3B5
UniProtKB E2RAM4 FCER1G GO:0051260 GO_REF:0000107 IEA UniProtKB:P30273|ensembl:ENSP00000289902 P Fc fragment of IgE receptor Ig FCER1G protein taxon:9615 20191109 Ensembl UniProtKB:E2RAM4
UniProtKB E2RDA4 VHL GO:0042803 GO_REF:0000107 IEA UniProtKB:O43187|ensembl:ENSP00000256458 F von Hippel-Lindau disease tumor suppressor VHL protein taxon:9615 20191109 Ensembl UniProtKB:E2RDA4
UniProtKB E2RS76 BLM GO:0042803 GO_REF:0000107 IEA UniProtKB:P54132|ensembl:ENSP00000347232 F BLM RecQ like helicase BLM protein taxon:9615 20191109 Ensembl UniProtKB:E2RS76
UniProtKB E2RS76 BLM GO:0051260 GO_REF:0000107 IEA UniProtKB:P54132|ensembl:ENSP00000347232 P BLM RecQ like helicase BLM protein taxon:9615 20191109 Ensembl UniProtKB:E2RS76
UniProtKB F1P843 ABCD3 GO:0042803 GO_REF:0000107 IEA UniProtKB:P28288|ensembl:ENSP00000359233 F ATP binding cassette subfamily D member 3 ABCD3 protein taxon:9615 20191109 Ensembl UniProtKB:F1P843
UniProtKB F1P8M9 EIF2AK1 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q9Z2R9|ensembl:ENSMUSP00000098056 F Protein kinase domain-containing protein EIF2AK1 protein taxon:9615 20191109 Ensembl UniProtKB:F1P8M9
UniProtKB F1PAJ8 KCTD14 GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD14 protein taxon:9615 20191109 InterPro UniProtKB:F1PAJ8
UniProtKB F1PAN9 BAX GO:0042803 GO_REF:0000107 IEA UniProtKB:Q07812|ensembl:ENSP00000293288 F BCL2 associated X, apoptosis regulator BAX protein taxon:9615 20191109 Ensembl UniProtKB:F1PAN9
UniProtKB F1PAN9 BAX GO:0051260 GO_REF:0000107 IEA UniProtKB:Q07812|ensembl:ENSP00000293288 P BCL2 associated X, apoptosis regulator BAX protein taxon:9615 20191109 Ensembl UniProtKB:F1PAN9
UniProtKB F1PAP9 RUVBL2 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q9WTM5|ensembl:ENSMUSP00000147502 F RuvB-like helicase RUVBL2 protein taxon:9615 20191109 Ensembl UniProtKB:F1PAP9
UniProtKB F1PB24 HIP1 GO:0042803 GO_REF:0000107 IEA UniProtKB:O00291|ensembl:ENSP00000336747 F Huntingtin interacting protein 1 HIP1 protein taxon:9615 20191109 Ensembl UniProtKB:F1PB24
UniProtKB F1PBM4 KCNC4 GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC4 protein taxon:9615 20191109 InterPro UniProtKB:F1PBM4
UniProtKB F1PF96 LPL GO:0042803 GO_REF:0000107 IEA UniProtKB:P06858|ensembl:ENSP00000497642 F Lipoprotein lipase LPL protein taxon:9615 20191109 Ensembl UniProtKB:F1PF96
UniProtKB F1PGG2 KCNC2 GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC2 protein taxon:9615 20191109 InterPro UniProtKB:F1PGG2
UniProtKB F1PKH0 TGFB2 GO:0042803 GO_REF:0000024 ISS UniProtKB:P61812 F Transforming growth factor beta TGFB2 protein taxon:9615 20141202 AgBase UniProtKB:F1PKH0
UniProtKB F1PKZ8 TRIM37 GO:0042803 GO_REF:0000107 IEA UniProtKB:O94972|ensembl:ENSP00000262294 F Tripartite motif containing 37 TRIM37 protein taxon:9615 20191109 Ensembl UniProtKB:F1PKZ8
UniProtKB F1PLK3 HCN1 GO:0051289 GO_REF:0000107 IEA UniProtKB:O60741|ensembl:ENSP00000307342 P Cyclic nucleotide-binding domain-containing protein HCN1 protein taxon:9615 20191109 Ensembl UniProtKB:F1PLK3
UniProtKB F1PM55 KCNC2 GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC2 protein taxon:9615 20191109 InterPro UniProtKB:F1PM55
UniProtKB F1PQR9 GPD1L GO:0042803 GO_REF:0000002 IEA InterPro:IPR017751 F Glycerol-3-phosphate dehydrogenase [NAD(+)] GPD1L protein taxon:9615 20191109 InterPro UniProtKB:F1PQR9
UniProtKB F1PRI9 DGAT2 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q9DCV3|ensembl:ENSMUSP00000033001 F Diacylglycerol O-acyltransferase 2 DGAT2 protein taxon:9615 20191109 Ensembl UniProtKB:F1PRI9
UniProtKB F1PS79 RANBP3L GO:0042803 GO_REF:0000104 IEA UniRule:UR000192082 F NAD kinase 2, mitochondrial RANBP3L protein taxon:9615 20191109 UniProt UniProtKB:F1PS79
UniProtKB F1PUQ2 NOS2 GO:0042803 GO_REF:0000107 IEA UniProtKB:P29477|ensembl:ENSMUSP00000018610 F Nitric oxide synthase NOS2 protein taxon:9615 20191109 Ensembl UniProtKB:F1PUQ2
UniProtKB F1PUW9 KIT GO:0042803 GO_REF:0000107 IEA UniProtKB:P10721|ensembl:ENSP00000288135 F Mast/stem cell growth factor receptor KIT protein taxon:9615 20191109 Ensembl UniProtKB:F1PUW9
UniProtKB F1PYL8 PECAM1 GO:0042803 GO_REF:0000107 IEA UniProtKB:P16284|ensembl:ENSP00000457421 F Platelet and endothelial cell adhesion molecule 1 PECAM1 protein taxon:9615 20191109 Ensembl UniProtKB:F1PYL8
UniProtKB F1PZR3 WRN GO:0042803 GO_REF:0000107 IEA UniProtKB:Q14191|ensembl:ENSP00000298139 F Werner syndrome RecQ like helicase WRN protein taxon:9615 20191109 Ensembl UniProtKB:F1PZR3
UniProtKB F1Q208 KCNH2 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q12809|ensembl:ENSP00000262186 F Cyclic nucleotide-binding domain-containing protein KCNH2 protein taxon:9615 20191109 Ensembl UniProtKB:F1Q208
UniProtKB F1Q234 ABCB9 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q9NP78|ensembl:ENSP00000440288 F Uncharacterized protein ABCB9 protein taxon:9615 20191109 Ensembl UniProtKB:F1Q234
UniProtKB F6UTK9 TRPM4 GO:0051289 GO_REF:0000107 IEA UniProtKB:Q7TN37|ensembl:ENSMUSP00000040367 P Transient receptor potential cation channel subfamily M member 4 TRPM4 protein taxon:9615 20191109 Ensembl UniProtKB:F6UTK9
UniProtKB F6UTK9 TRPM4 GO:0051289 GO_REF:0000107 IEA UniProtKB:Q8TD43|ensembl:ENSP00000252826 P Transient receptor potential cation channel subfamily M member 4 TRPM4 protein taxon:9615 20191109 Ensembl UniProtKB:F6UTK9
UniProtKB F6V057 ARNT GO:0042803 GO_REF:0000107 IEA UniProtKB:P27540|ensembl:ENSP00000351407 F Aryl hydrocarbon receptor nuclear translocator ARNT protein taxon:9615 20191109 Ensembl UniProtKB:F6V057
UniProtKB F6XSN6 PANK3 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q9H999|ensembl:ENSP00000239231 F Pantothenate kinase 3 PANK3 protein taxon:9615 20191109 Ensembl UniProtKB:F6XSN6
UniProtKB J9JH99 SKI GO:0070207 GO_REF:0000107 IEA UniProtKB:P12755|ensembl:ENSP00000367797 P c-SKI_SMAD_bind domain-containing protein SKI protein taxon:9615 20191109 Ensembl UniProtKB:J9JH99
UniProtKB J9JHB8 GRHL1 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q9NZI5|ensembl:ENSP00000324693 F CP2 domain-containing protein GRHL1 protein taxon:9615 20191109 Ensembl UniProtKB:J9JHB8
UniProtKB J9JHQ2 XDH GO:0042803 GO_REF:0000107 IEA UniProtKB:P47989|ensembl:ENSP00000368727 F Xanthine dehydrogenase XDH protein taxon:9615 20191109 Ensembl UniProtKB:J9JHQ2
UniProtKB J9NRU2 CNOT9 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q92600|ensembl:ENSP00000486540 F CCR4-NOT transcription complex subunit 9 CNOT9 protein taxon:9615 20191109 Ensembl UniProtKB:J9NRU2
UniProtKB J9NTH7 TFAP4 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q01664|ensembl:ENSP00000204517 F BHLH domain-containing protein TFAP4 protein taxon:9615 20191109 Ensembl UniProtKB:J9NTH7
UniProtKB J9NUF2 FLT4 GO:0042803 GO_REF:0000107 IEA UniProtKB:P35916|ensembl:ENSP00000261937 F Fms related tyrosine kinase 4 FLT4 protein taxon:9615 20191109 Ensembl UniProtKB:J9NUF2
UniProtKB J9NV20 KCNA7 GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNA7 protein taxon:9615 20191109 InterPro UniProtKB:J9NV20
UniProtKB J9NVN0 CIP2A GO:0042803 GO_REF:0000107 IEA UniProtKB:Q8TCG1|ensembl:ENSP00000295746 F Cell proliferation regulating inhibitor of protein phosphatase 2A CIP2A protein taxon:9615 20191109 Ensembl UniProtKB:J9NVN0
UniProtKB J9NVY5 TARBP2 GO:0042803 GO_REF:0000104 IEA UniRule:UR000106193 F RISC-loading complex subunit TARBP2 TARBP2 protein taxon:9615 20191109 UniProt UniProtKB:J9NVY5
UniProtKB J9NW47 MMAA GO:0042803 GO_REF:0000107 IEA UniProtKB:Q8IVH4|ensembl:ENSP00000497008 F Metabolism of cobalamin associated A MMAA protein taxon:9615 20191109 Ensembl UniProtKB:J9NW47
UniProtKB J9NX31 SYCP1 GO:0051289 GO_REF:0000107 IEA UniProtKB:Q15431|ensembl:ENSP00000358535 P Synaptonemal complex protein 1 SYCP1 protein taxon:9615 20191109 Ensembl UniProtKB:J9NX31
UniProtKB J9NXS0 TSC2 GO:0042803 GO_REF:0000107 IEA UniProtKB:P49815|ensembl:ENSP00000219476 F Rap-GAP domain-containing protein TSC2 protein taxon:9615 20191109 Ensembl UniProtKB:J9NXS0
UniProtKB J9NYC9 PDE2A GO:0042803 GO_REF:0000107 IEA UniProtKB:O00408|ensembl:ENSP00000334910 F GAF domain-containing protein PDE2A protein taxon:9615 20191109 Ensembl UniProtKB:J9NYC9
UniProtKB J9P151 MEF2D GO:0042803 GO_REF:0000107 IEA UniProtKB:Q63943|ensembl:ENSMUSP00000103184 F MADS-box domain-containing protein MEF2D protein taxon:9615 20191109 Ensembl UniProtKB:J9P151
UniProtKB J9P1C1 KIF20B GO:0042803 GO_REF:0000107 IEA UniProtKB:Q96Q89|ensembl:ENSP00000360793 F Kinesin motor domain-containing protein KIF20B protein taxon:9615 20191109 Ensembl UniProtKB:J9P1C1
UniProtKB J9P1W5 KCTD17 GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB_2 domain-containing protein KCTD17 protein taxon:9615 20191109 InterPro UniProtKB:J9P1W5
UniProtKB J9P2B3 KCTD17 GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB_2 domain-containing protein KCTD17 protein taxon:9615 20191109 InterPro UniProtKB:J9P2B3
UniProtKB J9P4J1 MORC2 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q9Y6X9|ensembl:ENSP00000380763 F CW-type domain-containing protein MORC2 protein taxon:9615 20191109 Ensembl UniProtKB:J9P4J1
UniProtKB J9P539 TERF1 GO:0042803 GO_REF:0000104 IEA UniRule:UR000734782 F Telomeric repeat-binding factor TERF1 protein taxon:9615 20191109 UniProt UniProtKB:J9P539
UniProtKB J9P6M8 RNF8 GO:0042803 GO_REF:0000104 IEA UniRule:UR000138767 F E3 ubiquitin-protein ligase RNF8 RNF8 protein taxon:9615 20191109 UniProt UniProtKB:J9P6M8
UniProtKB J9P7F0 ENG GO:0042803 GO_REF:0000107 IEA UniProtKB:Q63961|ensembl:ENSMUSP00000009705 F ZP domain-containing protein ENG protein taxon:9615 20191109 Ensembl UniProtKB:J9P7F0
UniProtKB J9P7U6 SHKBP1 GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein SHKBP1 protein taxon:9615 20191109 InterPro UniProtKB:J9P7U6
UniProtKB J9P7V6 NACC1 GO:0051260 GO_REF:0000107 IEA UniProtKB:Q96RE7|ensembl:ENSP00000292431 P BTB domain-containing protein NACC1 protein taxon:9615 20191109 Ensembl UniProtKB:J9P7V6
UniProtKB J9P8J7 SPPL3 GO:0042803 GO_REF:0000107 IEA UniProtKB:Q8TCT6|ensembl:ENSP00000288680 F Signal peptide peptidase like 3 SPPL3 protein taxon:9615 20191109 Ensembl UniProtKB:J9P8J7
UniProtKB J9P9P2 ATP2A1 GO:0042803 GO_REF:0000107 IEA UniProtKB:O14983|ensembl:ENSP00000349595 F Calcium-transporting ATPase ATP2A1 protein taxon:9615 20191109 Ensembl UniProtKB:J9P9P2
UniProtKB J9PA30 DISP1 GO:0070207 PMID:20023168 IDA P SSD domain-containing protein DISP1 protein taxon:9615 20170216 UniProt UniProtKB:J9PA30
UniProtKB L7N071 ACTN4 GO:0042803 GO_REF:0000107 IEA UniProtKB:O43707|ensembl:ENSP00000252699 F Actinin alpha 4 ACTN4 protein taxon:9615 20191109 Ensembl UniProtKB:L7N071
Annotations to ISS, ISA and ISO should not be self-referential