#Line number RuleID ViolationType Message Line #------------ #------------ # Validation for #145896 annotations in 145915 lines #------------ #Line number RuleID ViolationType Message Line #------------ # GO_AR:0000005 No ISS or ISS-related annotations to 'protein binding ; GO:0005515' Error count: 7 58583 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB E1BJ75 CRTAP GO:0005515 GO_REF:0000024 ISS UniProtKB:Q90830 F Cartilage associated protein CRTAP protein taxon:9913 20180925 UniProt 103955 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB P08169 IGF2R GO:0005515 GO_REF:0000024 ISS UniProtKB:P11717 F Cation-independent mannose-6-phosphate receptor IGF2R|M6P protein taxon:9913 20091210 UniProt 105560 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB P18341 TGFB1 GO:0005515 GO_REF:0000024 ISS UniProtKB:P01137 F Transforming growth factor beta-1 proprotein TGFB1 protein taxon:9913 20141202 AgBase 111560 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB P80012 VWF GO:0005515 GO_REF:0000024 ISS UniProtKB:P04275 F von Willebrand factor VWF|F8VWF protein taxon:9913 20070328 UniProt 111666 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB P80311 PPIB GO:0005515 GO_REF:0000024 ISS UniProtKB:P24367 F Peptidyl-prolyl cis-trans isomerase B PPIB protein taxon:9913 20180925 UniProt 131676 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB Q3MHX6 OS9 GO:0005515 GO_REF:0000024 ISS UniProtKB:Q13438 F Protein OS-9 OS9 protein taxon:9913 20090907 UniProt 132137 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB Q3SX24 FBXO6 GO:0005515 GO_REF:0000024 ISS UniProtKB:Q9QZN4 F F-box only protein 6 FBXO6|FBS2|FBX6 protein taxon:9913 20090903 UniProt #------------ # GO_AR:0000014 Valid GO term ID Error count: 15 30208 GO_AR:0000014 Error The id 'GO:1990967' in the annotation is an obsolete class UniProtKB A0A3S5ZPA2 RAB40B GO:1990967 GO_REF:0000107 IEA UniProtKB:Q12829|ensembl:ENSP00000461785 P SOCS box domain-containing protein RAB40B protein taxon:9913 20190925 Ensembl 38878 GO_AR:0000014 Error The id 'GO:1990967' in the annotation is an obsolete class UniProtKB A5PJV4 RAB29 GO:1990967 GO_REF:0000107 IEA UniProtKB:O14966|ensembl:ENSP00000356107 P RAB29, member RAS oncogene family RAB29|RAB7L1 protein taxon:9913 20190925 Ensembl 46371 GO_AR:0000014 Error The id 'GO:0052213' in the annotation is an obsolete class UniProtKB E1B726 PLG GO:0052213 GO_REF:0000107 IEA UniProtKB:P00747|ensembl:ENSP00000308938 P Plasminogen PLG protein taxon:9913 20190925 Ensembl 102378 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0010867 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001013),has_agent(UBERON:0002107),occurs_in(UBERON:0001911) 102378 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0010867 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001013),has_agent(UBERON:0002107),occurs_in(UBERON:0001911) 102388 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0045542 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001013),has_agent(UBERON:0002107),occurs_in(UBERON:0001911) 102388 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0045542 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001013),has_agent(UBERON:0002107),occurs_in(UBERON:0001911) 102390 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0045723 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001911),has_agent(UBERON:0002107),occurs_in(UBERON:0001013) 102390 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0045723 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001911),has_agent(UBERON:0002107),occurs_in(UBERON:0001013) 102391 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0045723 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001013),has_agent(UBERON:0002107),occurs_in(UBERON:0001911) 102391 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0045723 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001013),has_agent(UBERON:0002107),occurs_in(UBERON:0001911) 102396 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0071073 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001911),has_agent(UBERON:0002107),occurs_in(UBERON:0001013) 102396 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:0071073 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001911),has_agent(UBERON:0002107),occurs_in(UBERON:0001013) 102397 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:1900482 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001013),has_agent(UBERON:0002107),occurs_in(UBERON:0001911) 102397 GO_AR:0000014 Error The relation 'has_agent' in the c16 annotation extension is an obsolete relation UniProtKB P01246 GH1 GO:1900482 PMID:2731415 IDA P Somatotropin GH1|GH protein taxon:9913 20150522 AgBase happens_during(GO:0007595),has_agent(UBERON:0001013),has_agent(UBERON:0002107),occurs_in(UBERON:0001911) #------------ # GO_AR:0000003 Annotations to 'binding ; GO:0005488' and 'protein binding ; GO:0005515' should be made with IPI and an interactor in the 'with' field Warning count: 8 58583 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB E1BJ75 CRTAP GO:0005515 GO_REF:0000024 ISS UniProtKB:Q90830 F Cartilage associated protein CRTAP protein taxon:9913 20180925 UniProt 103165 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB P04272 ANXA2 GO:0005515 PMID:18597635 TAS F Annexin A2 ANXA2|ANX2 protein taxon:9913 20140514 AgBase 103955 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB P08169 IGF2R GO:0005515 GO_REF:0000024 ISS UniProtKB:P11717 F Cation-independent mannose-6-phosphate receptor IGF2R|M6P protein taxon:9913 20091210 UniProt 105560 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB P18341 TGFB1 GO:0005515 GO_REF:0000024 ISS UniProtKB:P01137 F Transforming growth factor beta-1 proprotein TGFB1 protein taxon:9913 20141202 AgBase 111560 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB P80012 VWF GO:0005515 GO_REF:0000024 ISS UniProtKB:P04275 F von Willebrand factor VWF|F8VWF protein taxon:9913 20070328 UniProt 111666 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB P80311 PPIB GO:0005515 GO_REF:0000024 ISS UniProtKB:P24367 F Peptidyl-prolyl cis-trans isomerase B PPIB protein taxon:9913 20180925 UniProt 131676 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB Q3MHX6 OS9 GO:0005515 GO_REF:0000024 ISS UniProtKB:Q13438 F Protein OS-9 OS9 protein taxon:9913 20090907 UniProt 132137 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB Q3SX24 FBXO6 GO:0005515 GO_REF:0000024 ISS UniProtKB:Q9QZN4 F F-box only protein 6 FBXO6|FBS2|FBX6 protein taxon:9913 20090903 UniProt #------------ # GO_AR:0000008 No annotations should be made to uninformative high level terms Warning count: 7 14343 GO_AR:0000008 Warning Do not annotate to: GO:0072001 'renal system development' The term is considered to high level, as marked via the subset tag: gocheck_do_not_annotate UniProtKB A0A3Q1M8K4 ITGA6 GO:0072001 GO_REF:0000107 IEA UniProtKB:P23229|ensembl:ENSP00000386896 P Integrin_alpha2 domain-containing protein ITGA6 protein taxon:9913 20190925 Ensembl 23652 GO_AR:0000008 Warning Do not annotate to: GO:0072001 'renal system development' The term is considered to high level, as marked via the subset tag: gocheck_do_not_annotate UniProtKB A0A3Q1MRM3 ITGB4 GO:0072001 GO_REF:0000107 IEA UniProtKB:P16144|ensembl:ENSP00000200181 P Integrin beta ITGB4 protein taxon:9913 20190925 Ensembl 47444 GO_AR:0000008 Warning Do not annotate to: GO:0072001 'renal system development' The term is considered to high level, as marked via the subset tag: gocheck_do_not_annotate UniProtKB E1B860 IFT140 GO:0072001 GO_REF:0000107 IEA UniProtKB:Q96RY7|ensembl:ENSP00000406012 P WD_REPEATS_REGION domain-containing protein IFT140 protein taxon:9913 20190925 Ensembl 47981 GO_AR:0000008 Warning Do not annotate to: GO:0072001 'renal system development' The term is considered to high level, as marked via the subset tag: gocheck_do_not_annotate UniProtKB E1B8M0 CEP55 GO:0072001 GO_REF:0000107 IEA UniProtKB:Q53EZ4|ensembl:ENSP00000360540 P EABR domain-containing protein CEP55 protein taxon:9913 20190925 Ensembl 59240 GO_AR:0000008 Warning Do not annotate to: GO:0072001 'renal system development' The term is considered to high level, as marked via the subset tag: gocheck_do_not_annotate UniProtKB E1BJT1 TBX18 GO:0072001 GO_REF:0000107 IEA UniProtKB:O95935|ensembl:ENSP00000358677 P T-box 18 TBX18 protein taxon:9913 20190925 Ensembl 111799 GO_AR:0000008 Warning Do not annotate to: GO:0005622 'intracellular' The term is considered to high level, as marked via the subset tag: gocheck_do_not_annotate UniProtKB P81287 ANXA5 GO:0005622 GO_REF:0000024 ISS UniProtKB:P08758 C Annexin A5 ANXA5|ANX5 protein taxon:9913 20061003 AgBase 124360 GO_AR:0000008 Warning Do not annotate to: GO:0005622 'intracellular' The term is considered to high level, as marked via the subset tag: gocheck_do_not_annotate UniProtKB Q2HJ92 PRKRA GO:0005622 GO_REF:0000024 ISS UniProtKB:Q9WTX2 C Interferon-inducible double-stranded RNA-dependent protein kinase activator A PRKRA protein taxon:9913 20070616 AgBase #------------ # GO_AR:0000014 Valid GO term ID Warning count: 22 6966 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A0A3Q1LUQ3 SOX11 GO:0001158 GO_REF:0000107 IEA UniProtKB:P35716|ensembl:ENSP00000322568 F Transcription factor SOX SOX11 protein taxon:9913 20190925 Ensembl 6967 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A0A3Q1LUQ3 SOX11 GO:0001158 GO_REF:0000107 IEA UniProtKB:Q7M6Y2|ensembl:ENSMUSP00000078070 F Transcription factor SOX SOX11 protein taxon:9913 20190925 Ensembl 10964 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A0A3Q1M323 LDB1 GO:0001158 GO_REF:0000107 IEA UniProtKB:P70662|ensembl:ENSMUSP00000118546 F LID domain-containing protein LDB1 protein taxon:9913 20190925 Ensembl 13453 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A0A3Q1M7A5 ZNF395 GO:0001158 GO_REF:0000107 IEA UniProtKB:E9Q5N9|ensembl:ENSMUSP00000064422 F C2H2-type domain-containing protein ZNF395 protein taxon:9913 20190925 Ensembl 13725 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A0A3Q1M7U2 TFAP2B GO:0001158 GO_REF:0000107 IEA UniProtKB:Q92481|ensembl:ENSP00000377265 F TF_AP-2 domain-containing protein TFAP2B protein taxon:9913 20190925 Ensembl 18475 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A0A3Q1MGB0 GATA3 GO:0001158 GO_REF:0000107 IEA UniProtKB:P23772|ensembl:ENSMUSP00000100041 F Trans-acting T-cell-specific transcription factor GATA-3 GATA3 protein taxon:9913 20190925 Ensembl 21802 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A0A3Q1MN22 SOX9 GO:0001158 GO_REF:0000107 IEA UniProtKB:Q04887|ensembl:ENSMUSP00000000579 F HMG box domain-containing protein SOX9 protein taxon:9913 20190925 Ensembl 25536 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A0A3Q1MWF9 IRF7 GO:0001158 GO_REF:0000107 IEA UniProtKB:P70434|ensembl:ENSMUSP00000026571 F IRF tryptophan pentad repeat domain-containing protein IRF7 protein taxon:9913 20190925 Ensembl 37911 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A5D7T6 YY1 GO:0001158 GO_REF:0000107 IEA UniProtKB:P25490|ensembl:ENSP00000262238 F YY1 protein YY1 protein taxon:9913 20190925 Ensembl 40074 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A6H796 ISL1 GO:0001158 GO_REF:0000107 IEA UniProtKB:P61371|ensembl:ENSP00000230658 F ISL LIM homeobox 1 ISL1 protein taxon:9913 20190925 Ensembl 44987 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB A7Z015 LHX1 GO:0001158 GO_REF:0000107 IEA UniProtKB:P63006|ensembl:ENSMUSP00000018842 F LHX1 protein LHX1 protein taxon:9913 20190925 Ensembl 47845 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB E1B8F2 FOXN4 GO:0001158 GO_REF:0000107 IEA UniProtKB:Q8K3Q3|ensembl:ENSMUSP00000047951 F Fork-head domain-containing protein FOXN4 protein taxon:9913 20190925 Ensembl 47846 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB E1B8F2 FOXN4 GO:0001158 GO_REF:0000107 IEA UniProtKB:Q96NZ1|ensembl:ENSP00000299162 F Fork-head domain-containing protein FOXN4 protein taxon:9913 20190925 Ensembl 56013 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB E1BGW3 ZBTB7B GO:0001158 GO_REF:0000107 IEA UniProtKB:Q64321|ensembl:ENSMUSP00000103058 F Zinc finger and BTB domain containing 7B ZBTB7B protein taxon:9913 20190925 Ensembl 79060 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB F1MT63 HOXD13 GO:0001158 GO_REF:0000107 IEA UniProtKB:P70217|ensembl:ENSMUSP00000001872 F Homeobox domain-containing protein HOXD13 protein taxon:9913 20190925 Ensembl 81407 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB F1MWE1 ZNF704 GO:0001158 GO_REF:0000107 IEA UniProtKB:Q9ERQ3|ensembl:ENSMUSP00000041242 F C2H2-type domain-containing protein ZNF704 protein taxon:9913 20190925 Ensembl 107870 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB P40673 HMGB2 GO:0001158 GO_REF:0000024 ISS UniProtKB:P30681 F High mobility group protein B2 HMGB2|HMG2 protein taxon:9913 20150512 AgBase 107871 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB P40673 HMGB2 GO:0001158 GO_REF:0000024 ISS UniProtKB:Q3U566 F High mobility group protein B2 HMGB2|HMG2 protein taxon:9913 20150512 AgBase 116488 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB Q0V8E2 TBX19 GO:0001158 GO_REF:0000107 IEA UniProtKB:Q99ME7|ensembl:ENSMUSP00000027859 F T-box 19 TBX19 protein taxon:9913 20190925 Ensembl 133778 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB Q3SZZ2 XBP1 GO:0001158 GO_REF:0000024 ISS UniProtKB:P15336 F X-box-binding protein 1 XBP1 protein taxon:9913 20141022 UniProt 133779 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB Q3SZZ2 XBP1 GO:0001158 GO_REF:0000024 ISS UniProtKB:P17861 F X-box-binding protein 1 XBP1 protein taxon:9913 20141022 UniProt 137606 GO_AR:0000014 Warning The id 'GO:0001158' in the annotation is an alternate id for: GO:0000987 UniProtKB Q4JM65 NANOG GO:0001158 GO_REF:0000107 IEA UniProtKB:Q80Z64|ensembl:ENSMUSP00000012540 F Homeobox protein NANOG NANOG protein taxon:9913 20190925 Ensembl #------------