Table of contents

Summary

GAF summary

Found 144137 annotations in 144153 lines.

GAF Validation Summary Errors are reported first.

For rule GO_AR:0000005 (http://www.geneontology.org/GO.annotation_qc.shtml#GO_AR:0000005) No ISS or ISS-related annotations to 'protein binding ; GO:0005515', there are 3 violations with type Error.

For rule GO_AR:0000003 (http://www.geneontology.org/GO.annotation_qc.shtml#GO_AR:0000003) Annotations to 'binding ; GO:0005488' and 'protein binding ; GO:0005515' should be made with IPI and an interactor in the 'with' field, there are 3 violations with type Warning.

GAF Prediction Summary

Found 33 predictions, see prediction file for details.

Used Ontology Summary

go/extensions/go-gaf

Report

SUMMARY

STATISTICS

MESSAGES

ERROR

WARNING

OWLTools check

#Line number RuleID ViolationType Message Line
#------------
#------------
# Validation for #144137 annotations in 144153 lines
#------------
#Line number RuleID ViolationType Message Line
#------------
# GO_AR:0000005 No ISS or ISS-related annotations to 'protein binding ; GO:0005515' Error count: 3
128020 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB K7GQZ2 TGFB1 GO:0005515 GO_REF:0000024 ISS UniProtKB:P01137 F Transforming growth factor beta-1 TGFB1 protein taxon:9823 20141202 AgBase
132246 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB P07200 TGFB1 GO:0005515 GO_REF:0000024 ISS UniProtKB:P01137 F Transforming growth factor beta-1 TGFB1 protein taxon:9823 20141202 AgBase
137309 GO_AR:0000005 Error No ISS or ISS-related annotations to 'protein binding ; GO:0005515' UniProtKB Q28833 VWF GO:0005515 GO_REF:0000024 ISS UniProtKB:P04275 F von Willebrand factor VWF|F8VWF protein taxon:9823 20070328 UniProt
#------------
# GO_AR:0000003 Annotations to 'binding ; GO:0005488' and 'protein binding ; GO:0005515' should be made with IPI and an interactor in the 'with' field Warning count: 3
128020 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB K7GQZ2 TGFB1 GO:0005515 GO_REF:0000024 ISS UniProtKB:P01137 F Transforming growth factor beta-1 TGFB1 protein taxon:9823 20141202 AgBase
132246 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB P07200 TGFB1 GO:0005515 GO_REF:0000024 ISS UniProtKB:P01137 F Transforming growth factor beta-1 TGFB1 protein taxon:9823 20141202 AgBase
137309 GO_AR:0000003 Warning Annotations to 'binding' (GO:0005488) and 'protein binding' (GO:0005515) should be made with an IPI evidence code and the interactor in the 'with' field UniProtKB Q28833 VWF GO:0005515 GO_REF:0000024 ISS UniProtKB:P04275 F von Willebrand factor VWF|F8VWF protein taxon:9823 20070328 UniProt
#------------

Predictions

GO:0005622 intracellular AnnotationPropagation C GO:0042147 retrograde transport, endosome to Golgi ISS
GO:0005623 cell AnnotationPropagation C GO:0042147 retrograde transport, endosome to Golgi ISS
GO:0005829 cytosol AnnotationPropagation C GO:0042147 retrograde transport, endosome to Golgi ISS
GO:0005622 intracellular AnnotationPropagation C GO:0097193 intrinsic apoptotic signaling pathway ISS
GO:0055114 oxidation-reduction process AnnotationPropagation P GO:0097257 leukotriene B4 12-hydroxy dehydrogenase activity TAS
GO:0005623 cell AnnotationPropagation C GO:0051480 regulation of cytosolic calcium ion concentration ISS
GO:0006508 proteolysis AnnotationPropagation P GO:0070006 metalloaminopeptidase activity ISS
GO:0071108 protein K48-linked deubiquitination AnnotationPropagation P GO:1990380 Lys48-specific deubiquitinase activity ISS
GO:0005622 intracellular AnnotationPropagation C GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
GO:0016311 dephosphorylation AnnotationPropagation P GO:0052834 inositol monophosphate phosphatase activity ISS
GO:0120009 intermembrane lipid transfer AnnotationPropagation P GO:0120013 intermembrane lipid transfer activity ISS
GO:0005623 cell AnnotationPropagation C GO:0035356 cellular triglyceride homeostasis ISS
GO:0005622 intracellular AnnotationPropagation C GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway ISS
GO:0030974 thiamine pyrophosphate transmembrane transport AnnotationPropagation P GO:0090422 thiamine pyrophosphate transmembrane transporter activity ISS
GO:0035461 vitamin transmembrane transport AnnotationPropagation P GO:0090422 thiamine pyrophosphate transmembrane transporter activity ISS
GO:0005739 mitochondrion AnnotationPropagation C GO:0090615 mitochondrial mRNA processing ISS
GO:0005622 intracellular AnnotationPropagation C GO:0072425 signal transduction involved in G2 DNA damage checkpoint ISS
GO:0005739 mitochondrion AnnotationPropagation C GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
GO:0006468 protein phosphorylation AnnotationPropagation P GO:0050254 rhodopsin kinase activity ISS
GO:0005622 intracellular AnnotationPropagation C GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway ISS
GO:0005622 intracellular AnnotationPropagation C GO:0097193 intrinsic apoptotic signaling pathway ISS
GO:0005622 intracellular AnnotationPropagation C GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway ISS
GO:0006508 proteolysis AnnotationPropagation P GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS
GO:0006915 apoptotic process AnnotationPropagation P GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS
GO:0097190 apoptotic signaling pathway AnnotationPropagation P GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS
GO:0006468 protein phosphorylation AnnotationPropagation P GO:0070123 transforming growth factor beta receptor activity, type III ISS
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway AnnotationPropagation P GO:0070123 transforming growth factor beta receptor activity, type III ISS
GO:0005739 mitochondrion AnnotationPropagation C GO:0097345 mitochondrial outer membrane permeabilization ISS
GO:0005623 cell AnnotationPropagation C GO:0051480 regulation of cytosolic calcium ion concentration ISS
GO:0010452 histone H3-K36 methylation AnnotationPropagation P GO:0046975 histone methyltransferase activity (H3-K36 specific) ISS
GO:0097223 sperm part FoldBasedPredictor GO:0045177 apical part of cell exists_during GO:0048240 sperm capacitation part_of CL:0000019 sperm IDA
GO:0006858 extracellular transport FoldBasedPredictor GO:0045056 transcytosis occurs_in GO:0034364 high-density lipoprotein particle occurs_in UBERON:0000201 endothelial blood brain barrier IMP
GO:0034364 high-density lipoprotein particle FoldBasedPredictor GO:0045056 transcytosis occurs_in GO:0034364 high-density lipoprotein particle occurs_in UBERON:0000201 endothelial blood brain barrier IMP

Predictions (experimental)